•Propertics: The product has a slightly thickened texture and appears as a pale-yellow clear liquid.Pharmacological effects: Fipronil binds to the Y-aminobutyric acid (GABA) receptor on the central nerve cells ofinsects, blocks the floating ion channel of nerve cells, and interferes with the central nervous system of insectsand mites. The normal function of insects and mites caused the central nervous system to be overexcited and die.
•Fipronil is a highly lipophilic drug that is administered topically on the pet's skin, specifically between the shoulder blades. Once applied, it diffuses through the skin's surface oil and spreads throughout the entire bodywithin 24 hours. The drug is stored in the sebaceous glands, and continuous sebum secretion releases it onto theskin and hair. Although only a small amount is absorbed into the bloodstream through the skin, the distribution isextensive, with a primary accumulation in adipose tissue.Once inside the body,Fipronil undergoes metabolism,primarily transforming into its sulfonyl product, and no unchanged Fipronil is excreted through urine or feces.
•Instructions: To apply the medicine on the pet's skin, first, part the hair along the midline of the neck and backto reveal the skin. Then, place the nozzle on the exposed skin and gently press the medicine tube to ensure theliquid spreads evenly over the surface. Allow the medicine to air dry. For areas or instances with flea infection,apply the medicine once every month.